Our method for imaging Pgp activity can be used to identify multidrugresistant tumors or to determine the contribution of Pgp polymorphism, inhibition, or induction to interindividual variability in drug response.Īs her battles grow more desperate and more people she cares for fall victim to the Elder Bairns, Saya begins finding faults in her reality, and eventually uncovers a disturbing truth about herself, the town and her surviving friends. The modest inhibition of human BBB Pgp by cyclosporine has implications for Pgpbased drug interactions at the human BBB. The corresponding increases for the brain white and gray matter were 84 13 and 84 18, respectively. The brain uptake of 11 Cradioactivity (brain area under the curve AUC brain blood area under the curve AUC blood ) was determined in the presence and absence of cyclosporine. The content of verapamil and its metabolites in the 20 and 45minute plasma samples was determined by a rapid solidphase extraction method. To determine the importance of Pgp at the human BBB, we developed a stateoftheart, noninvasive, quantitative imaging technique to measure Pgp activity by use of carbon 11labeled verapamil as the Pgp substrate and cyclosporine (INN, ciclosporin) as the Pgp inhibitor.īoth blood and plasma radioactivity contents were determined in each verapamil sample. Blood Kisses 2005 Online Series Started Serialization.
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